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Addisyn Fair as "Baby Carmen"
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Alan Cumming as "Fegan Floop"
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Alexa Vega as "Carmen Cortez"
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Andy W. Bossley as "Brat"
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Angela Lanza as "Newscaster"
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Antonio Banderas as "Gregorio Cortez"
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Carla Gugino as "Ingrid Cortez"
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Charles Ramirez-Berg as "Financier"
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Cheech Marin as "Felix Gumm"
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Danny Trejo as "Machete"
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Daryl Sabara as "Juni Cortez"
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Dick Clark as "Financier"
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Ermahn Ospina as "Cab Driver"
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Evan Sabara as "'Intruder' Spy Kid"
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George Clooney as "Devlin"
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Guillermo Navarro as "Pastor"
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Houston Hooker as "Lisp's Robot Son"
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Johnny Reno as "Agent Johnny"
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Julio Villareal as "Spy Driver"
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Kara Slack as "Carmen's Friend"
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Louis Black as "Financier"
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Mike Judge as "Donnagon/Donnamight"
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Norman Cabrera as "FoOglie #2/Tall & Skinny"
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Patricia Vonne as "Spy Bridesmaid"
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Rachel Duhame as "President's Robot Daughter"
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Richard Linklater as "Cool Spy"
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Robert Patrick as "Mr. Lisp"
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Shannon Shea as "FoOglie #1/Flower"
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Steve Havens as "Financier"
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Teri Hatcher as "Ms. Gradenko"
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Tony Shalhoub as "Alexander Minion"
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Trant Batey as "FoOglie #3/Too Too"